Genomic dissection of travel-associated extended-spectrum-beta-lactamase-producing Salmonella enterica serovar typhi isolates originating from the Philippines: a one-off occurrence or a threat to effective treatment of typhoid fever?
نویسندگان
چکیده
One unreported case of extended-spectrum-beta-lactamase (ESBL)-producing Salmonella enterica serovar Typhi was identified, whole-genome sequence typed, among other analyses, and compared to other available genomes of S. Typhi. The reported strain was similar to a previously published strain harboring blaSHV-12 from the Philippines and likely part of an undetected outbreak, the first of ESBL-producing S. Typhi.
منابع مشابه
Detection of Extended Spectrum Beta Lactamase Producing Salmonella spp. and Multidrug Resistance Pattern
Background: and Objectives: Salmonella infections are endemic in many developing countries with poor sanitary conditions, but emerge sporadically as a serious public health threat in developed countries. Infections with multidrug resistant (MDR) strains of Salmonella have been associated with treatment failures. Salmonella spp. resistant to extended spectrum cephal...
متن کاملExtended-spectrum-beta-lactamase production in a Salmonella enterica serotype Typhi strain from the Philippines.
A Salmonella enterica serotype Typhi strain was cultured from blood and fecal samples from a 54-year-old man with fever and diarrhea. He had returned from travel to the Philippines a few days earlier. Phenotypic and genotypic analysis confirmed the production of the SHV-12 extended-spectrum beta-lactamase.
متن کاملSalmonella enterica: Serotyping, Drug Resistance & Extended Spectrum of β-Lactamase (ESBLs)
Background & Objective: Genus Salmonella has more than 2400 serotypes. The two major groups are S.enterica and S.bongori. Important serotypes are situated in S.enterica group. Antibiotic therapy in salmonellosis is restricted to typhoid fever and acute infections. After the first reporting of resistance in S.Typhimurium DT 104, nowadays, developing of resistance in Salmonella, specially, ESBL p...
متن کاملESBL-Producing Salmonella enterica Serovar Typhi in Traveler Returning from Guatemala to Spain
We report a case of typhoid fever in a traveler returning to Spain from Guatemala that was caused by Salmonella enterica serovar Typhi which produced an extended-spectrum β-lactamase (ESBL). This finding demonstrates the presence of ESBL-producing S. enterica ser. Typhi strains in the Americas. Enhanced surveillance is necessary to prevent further spread.
متن کاملEmergence of an Extensively Drug-Resistant Salmonella enterica Serovar Typhi Clone Harboring a Promiscuous Plasmid Encoding Resistance to Fluoroquinolones and Third-Generation Cephalosporins
Antibiotic resistance is a major problem in Salmonella enterica serovar Typhi, the causative agent of typhoid. Multidrug-resistant (MDR) isolates are prevalent in parts of Asia and Africa and are often associated with the dominant H58 haplotype. Reduced susceptibility to fluoroquinolones is also widespread, and sporadic cases of resistance to third-generation cephalosporins or azithromycin have...
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ورودعنوان ژورنال:
- Journal of clinical microbiology
دوره 53 2 شماره
صفحات -
تاریخ انتشار 2015